Effect of Positive End-expiratory Pressure Ventilation Under Mild Hypothermia on Oxygen Metabolism and Prognosis in Adult Acute Respiratory Distress Syndrome
Objective:To observe the effect of PEEP under mild hypothermia on improving the oxygen metabolism and prognosis of adult ARDS.Methods:126 adult patients with ARDS who received continuous positive pressure ventilation treatment in ICU of the hospital from May 2021 to May 2022 were selected as the study subjects.The patients were divided into two groups by drawing lots.Among them,63 patients in the control group were treated with PEEP under normal temperature,and 63 patients in the observation group were treated with PEEP under mild hypothermia.The changes of lung inflammation index,oxygen metabolism index,and the treatment and prognosis of the two groups were compared before and after treatment.Results:After different treatment,the local IL-6,the serum PCT and CRP were lower than the control group(t=4.973,6.714,4.442;P＜0.05).P/F,SvO2 were higher than those in the control group.LAC was lower than that in the control group(t=2.901,2.974,10.809;P＜0.05).The lung compliance of the observation group was higher than that of the control group,the length of hospitalization in ICU and the length of mechanical ventilation were lower than those of the control group(t=9.476,6.907,3.530;P＜0.05).The complication rate(7.94%)and the mortality rate(4.76%)were lower than those in the control group 15.87%(χ2=5.287,6.671;P＜0.05).Conclusion:The use of mild hypothermia combined with PEEP can promote the recovery of pulmonary inflammatory reaction and oxygen metabolism in adult patients with ARDS,increase the clinical benefits of patients,and improve the prognosis.
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