基于心脏电生理的心律失常控制策略
Trategies for Arrhythmia Control Based on Cardiac Electrophysiology
谢明希 1杨焕彤 1陈楚楚 1罗思祺 1许钊源1
作者信息
- 1. 广西医科大学基础医学院,广西 南宁 530100
- 折叠
摘要
螺旋波在心肌组织和化学反应等系统中普遍存在.螺旋波的自组织行为与心脏病患者出现的心律失常有着极为密切的关系.光遗传学与圆极化电场方法均对心律失常的控制有显著的效果.为了深入理解与研究基于心脏电生理的心律失常控制策略,对临床上心律失常的防治提供积极的科学参考意义,本文综述了圆极化电场和光遗传学方法对可激发介质中螺旋波的控制,包括圆极化电场对心脏组织中螺旋波的去钉扎机制、圆极化电场对心脏组织中螺旋波湍流态的控制作用、光敏蛋白在心脏电生理的应用、光遗传学数值模拟在心脏电生理的应用等.
Abstract
Spiral waves are prevalent in systems,such as myocardial tissue and chemical reactions.The self-organized behavior of spiral waves is closely related to arrhythmias in patients with heart disease.Both optogenetic and circularly polarized electric field methods have shown significant effects on arrhythmia control.To gain insight into and study strategies for arrhythmia control based on cardiac electrophysiology,and provide positive scientific reference for clinical arrhythmia prevention and treatment,the study reviews the effects of circularly polarized electric fields and optogenetic methods for controlling spiral waves in excitable media,including the depinning mechanism of spiral waves in cardiac tissue by circularly polarized electric fields,the control of spiral wave turbulent flow regimes in cardiac tissue by circularly polarized electric fields.Light sensitive proteins in cardiac electrophysiology,optogenetic numerical modeling in cardiac electrophysiology,etc.
关键词
螺旋波/心脏电生理/圆极化电场/光遗传学/控制/光敏蛋白Key words
Spiral wave/Cardiac electrophysiology/Circularly polarized electric fields/Optogenetics/Control/Photosensitive protein引用本文复制引用
出版年
2024
NETL
NSTL
万方数据