Association of CYP3A4,CYP3A5,POR and ABCB1 Gene Polymorphisms with Tacrolimus Plasma Concentration and Adverse Reactions in Children with Primary Nephrotic Syndrome
Objective:To explore the relationship between CYP3A4,CYP3A5,POR and ABCB1 gene polymorphisms,tacrolimus plasma concentration and adverse reactions in children with primary nephrotic syndrome.Methods:Collecting 120 children diagnosed with primary nephrotic syndrome and taking tacrolimus in the hospital from October 2018 to October 2019,testing their CYP3A4(rs2242480),CYP3A5(rs776746),POR(rs1057868)and ABCB1(rs1128503)genotypes,and conducting clinical data for analysis.Results:A total of 120 children with primary nephrotic syndrome were included in the analysis,the plasma concentration of children with CYP3A5 AA genotype(non expression group)was higher than that of GG and GA genotypes(expression group),and the difference was statistically significant(t=-9.225,P＜0.001).In the CYP3A5 of expression and non expression groups,the different genotypes of CYP3A4,POR and ABCB1 were not related to the plasma concentration of tacrolimus,and the difference was not statistically significant(P＞0.05).The adverse drug reactions of liver injury and kidney injury in children with CYP3A5 non expression group were significantly higher than expression group(P＜0.05).The results of logistic regression analysis showed that compared with the non expression group of CYP3A5,the risk of liver injury and kidney injury in children with the expression group was reduced by 0.31 and 0.32 times.The different genotypes of CYP3A4,PRO,and ABCB1 were not associated with related adverse reaction,and the differences were not statistically significant(P＞0.05).Conclusion:CYP3A5 gene polymorphism is associated with tacrolimus plasma concentration in children with primary nephrotic syndrome,and non expression genes will increase the risk of liver and kidney injury.
万方数据
维普
