Influence of Ultrasound-guided SAPB and Flurbiprofen on the Immune Response and SP and NPY Levels in Patients Undergoing Thoracoscopic Lobectomy
Objective:To investigate the effects of ultrasound-guided SAPB combined with flurbiprofen axidate on immune response,SP and NPY levels in patients undergoing thoracoscopic lobectomy.Methods:A total of 60 patients who underwent thoracoscopic lobectomy in the hospital from August 2022 to March 2023 were randomly divided into two groups,with 30 cases in each group.The control group(group C)was given conventional anesthesia,and the observation group(group S)was given SAPB combined with flurbiprofen axidate under the guidance of ascending ultrasound on the basis of conventional anesthesia.The postoperative analgesia effect,morphine consumption within 24 h after surgery,postoperative recovery,serum levels of IL-6,IL-10,TNF-α,SP and NPY 1 h and 24 h after surgery were compared between the two groups.Results:VAS scores of postoperative resting pain and activity pain in group S were lower than those in group C,and the difference was statistically significant(t=9.494,8.859,8.647,8.764;t=9.351,9.129,10.769,9.608;P＜0.05).The postoperative recovery of patients in group S was good,and compared with group C,the postoperative recovery room(PACU)residence time,extubation time and hospital stay were shortened,with statistically significant difference(t=7.843,6.234,4.562;P＜0.05).The serum levels of IL-6,TNF-α and SP in group S were lower than those in group C 1 h and 24 h after surgery,and the levels of IL-10 and NPY were higher than those in group C,with statistically significant difference(t=5.833,5.534;t=5.263,4.498;t=4.93,4.457;t=5.507,5.822;t=4.277,3.506;P＜0.05).Conclusion:Ultrasound-guided SAPB combined with flurbiprofen axidate can improve postoperative analgesia,reduce morphine consumption,promote postoperative recovery in patients undergoing thoracoscopic lobectomy,inhibit inflammatory response and stress response,and regulate immune response,SP and NPY levels.
SAPB under ultrasonic guidanceFlurbiprofen esterThoracoscopic lobectomyImmune responseSPNPY
万方数据
维普
