Objective:To compare the effects of combined thoracic paravertebral blocked and general anesthesial on myocardial protection,IL-6 and IL-1β in patients undergoing laparoscopic cholecystectomy.Methods:Patients were selected from June 2020 to February 2022.All patients were randomly divided into group T(received thoracic paravertebal blocked combined general anesthesial,n=30)and group G(general anesthesial,n=30).Bilateral paravertebral nerve block(T8～T9)under ultrasound guidance was performed in group T before general anesthesia induction,and general anesthesia induction was performed in group G after successful anesthesia induction.Hemodynamic stability was maintained,and end-expiratory carbon dioxide was continuously monitored in both groups.3 mL of venous blood was collected at T0(5 min before anesthesia),T1(at the end of surgery),T2(24 h after surgery)and T3(48 h after surgery)to detect the changes of serum cardiac troponin Ⅰ(cTnI),myocardial creatine kinase isoenzyme(CK-MB),IL-6 and IL-1β(ELISA).Results:At T1～T3,the increase degree of various indexes in group T was significantly lower than that in group G,and the difference was statistically significant(P＜0.05).The NRS score,remifentanil dosage,the number of effective analgesic pump compression and the number of postoperative nausea and vomiting cases in T group were significantly lower than those in G group,with statistically significant difference(P＜0.05).Conclusion:TPVB has myocardial protection in LC patients.
维普
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