Distribution and Drug Resistance Analysis of Blood Culture Pathogens in a Hospital in the Past 6 Years
Objective:To analyze the distribution and drug resistance of pathogenic bacteria in blood culture samples of patients with blood flow infection,in order to provide clinical rational drug use and treatment plan.Methods:Retrospectively analyzing the isolated strains of positive specimens from the blood culture in the Hui Ya Hospital of The First Affiliated Hospital,Sun Yat-Sen University from January 2017 to December 2022.Results:A total of 207 non repetitive strains were isolated from January 2017 to December 2019,and a total of 285 non repetitive strains were isolated from January 2020 to December 2022.The gram-negative bacteria were dominant,followed by gram-positive bacteria and fungi.The detection rates of Escherichia coli in bloodstream infections have increased,however,the detection rates of ESBLs in Escherichia coli were on the decline.No carbapenem resistant Escherichia coli was detected.Amikacin,cefoperazone/sulbactam maintained high antibacterial activity against Klebsiella pneumoniae.Staphylococcus was highly resistant to penicillin,and no strains resistant to vancomycin,linezolid and tigecycline were found.The detection rate of Enterococcus and non fermenting strains was low.Conclusion:The bacteria isolated from positive blood culture in this hospital are mainly Gram negative bacteria,and Escherichia coli is the most common pathogenic bacteria for bloodstream infections.Different pathogens have great differences in drug resistance.Patients with unexplained fever or suspected bloodstream infection should have timely and standardized submission of blood culture before antibiotic use.It's important for clinical diagnosis and treatment of bloodstream infections and the rational use of antibiotics.
万方数据
维普
