Changes of HMGB1 and IL-32 Levels in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Their Effects on Prognosis
Objective:To investigate the changes of high mobility group protein B1(HMGB1)and interleukin-32(IL-32)levels in peripheral blood of patients with systemic lupus erythematosus(SLE)and their effects on prognosis.Methods:168 patients with SLE admitted to the hospital from May 2020 to May 2022 were studied.According to whether permanent organ injury occurred 6 months after treatment,patients were divided into poor prognosis group(54 cases with permanent organ injury)and good prognosis group(114 cases with no permanent organ injury).According to SLEDAI score of SLE activity on admission,patients were inactive(58 cases with 0～4 points)and patients with mild activity(43 cases with 5～9 points),moderate activity(35 cases with 10～14 points)and severe activity(32 cases with≥15 points)were subgroups.The levels of HMGB1 and IL-32 in peripheral blood of patients with different activity levels at admission and at different time points of the two groups were compared,the correlation between the levels of HMGB1 and IL-32 in peripheral blood and SLEDAI score at admission was analyzed,and the predictive value of combined detection of peripheral blood HMGB1 and IL-32 in SLE patients was analyzed by ROC.Risk assessment of the impact of various indicators on poor prognosis in SLE patients was also analyzed.Results:After 1 month and 3 months,the levels of HMGB1 and IL-32 in peripheral blood of the poor prognosis group were higher than those of the good prognosis group(t=14.486,25.838,13.067,26.499;P＜0.05).The levels of HMGB1 and IL-32 in peripheral blood of inactive patients at admission were lower than those of mildly active patients,moderately active patients and severely active patients(F=347.793,201.076;P＜0.05).Correlation analysis showed that SLEDAI score was positively correlated with HMGB1 and IL-32 levels in peripheral blood at admission(r=0.639,0.577;P＜0.05).1 month and 3 months after treatment,the AUC of peripheral blood HMGB1 and IL-32 combined to predict poor prognosis of SLE were 0.751 and 0.833,respectively,and the optimal sensitivity and specificity were(85.19%,64.91% )and(96.30%,70.18% ),respectively,which were higher than the single prediction of each indicator 1 and 3 months after treatment,the risk of poor prognosis in patients with high levels of HMGB1 and IL-32 in peripheral blood was 2.903,1.885,3.333,2.554 times higher than that in patients with low levels(P＜0.05).Conclusion:HMGB1 and IL-32 levels in peripheral blood are closely related to activity and prognosis of SLE patients,and have reliable value in the diagnosis and prognosis evaluation of SLE.
Systemic lupus erythematosusPrognosisHigh mobility group protein B1Interleukin-32
万方数据
维普
