Effects of Ticagrelor Combined with Xuefu Zhuyu Capsule on Myocardial Microcirculation and Adverse Cardiovas-cular Events After PCI for ST Segment Elevation Myocardial Infarction
Objective:To investigate the effect of Ticagrelor combined with Xuefu Zhuyu capsule on myocardial microcirculation and adverse cardiovascular events after percutaneous coronary intervention(PCI)for ST segment elevation myocardial infarction(STEMI).Methods:80 patients with STEMI who were scheduled to undergo PCI in the hospital from January 2020 to October 2022 were selected as subjects for a prospective cohort study.According to the 1∶1 principle and the random number table,they were divided into the conventional group and the combined group,with 40 cases in each group.The routine group was treated with Ticagrelor,and the combined group was treated with Xuefu Zhuyu Capsule.The general data,cardiac function[(SVI),left ventricular ejection fraction(LVEF),left ventricular systolic pressure(LVSP)],myocardial microcirculation[myocardial infarction contrast media start perfusion time(AT),perfusion peak time(APT),perfusion peak intensity(PI),inflammatory indicators[high-sensitivity C-reactive protein(hs-CRP),intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-α(TNF-α)],adverse cardiovascular events were compared.Results:The combined group had higher LVEF,SVI and LVSP after treatment compared to the conventional group(t=4.007,4.716,2.887;P＜0.05).The improvement of APT,AT and PI in the combined group after treatment was greater than that in the conventional group(t=3.086,3.114,2.363;P＜0.05).After combined treatment with hs-CRP and TNF-α,the level of ICAM-1 was lower than that of the conventional group(t=3.633,3.092,8.277;P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse cardiovascular events between the combination group and the conventional group(P＞0.05).Conclusion:Ticagrelor combined with Xuefu Zhuyu capsule can improve microcirculation disorder,reduce inflammation and adhesion reaction,and promote cardiac function recovery in patients with STEMI after PCI.
万方数据
维普
