Analysis of Pathogenic Bacteria Distribution and Drug Resistance in Patients with Chronic Obstructive Pulmonary Disease Complicated with Lower Respiratory Tract Infection in Acute Exacerbation Stage
Objective:To analyze the distribution characteristics and drug resistance of pathogenic bacteria in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with lower respiratory tract infection.Methods:A retrospective analysis was conducted on the clinical data of 80 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)admitted to the hospital from February 2021 to February 2022.The sputum samples of the patients were identified for bacterial strains and tested for drug sensitivity.The composition of the patient's pathogen spectrum and the resistance of common pathogens was analyzed.Results:A total of 104 strains of pathogenic bacteria were isolated from the sputum samples of 80 AECOPD patients with lower respiratory tract infection.Gram negative bacteria accounted for 62.50%,Gram positive bacteria accounted for 26.92%,and fungi accounted for 10.58%.Among them,≥2 pathogens were isolated from the sputum samples of 19 patients.The main strains of Gram negative bacteria were Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii.The main strains of Gram positive bacteria were Staphylococcus aureus,Streptococcus pneumoniae,and Hemolytic staphylococcus.Cefazolin had high resistance to gram-negative bacteria,tobramycin and imipenem had low resistance to gram-negative bacteria.Penicillin G,levofloxacin and clindamycin had high resistance to gram-positive bacteria with no resistance to oxacillin,linezolid and vancomycin,and with low resistance to tetracycline.Other pathogens had large differences in resistance to different drugs.Conclusion:The main pathogenic bacteria in AECOPD patients with lower respiratory tract infection are Gram negative bacteria.There are significant differences in drug resistance among different drugs and bacteria.
Acute exacerbation of chronic obstructive pulmonary diseaseLower respiratory tract infectionDistribution of pathogenic bacteriaDrug resistance
万方数据
维普
