Objective:To explore the clinical significance of cell wax block combined with immunohistochemistry in the diagnosis of malignant serosal effusion,in order to provide reference data for early clinical treatment.Methods:A total of 83 patients with serosal effusion admitted to the hospital from May 2019 to February 2023 were selected as the study subjects.All of them were examined by cell wax block and immunohistochemistry.The diagnostic value(sensitivity,specificity,accuracy,positive predictive value and negative predictive value)and type detection rate of cell wax block combined with immunohistochemistry were analyzed with pathological examination as the gold standard.Results:The pathological biopsy results were 40 malignant cases and 43 benign cases.The diagnostic sensitivity,accuracy and negative predictive value of cell wax block+immunohistochemistry were higher than those of single cell wax block and immunohistochemistry(χ2=19.781,8.910,12.019;P＜0.05).Compared with cell wax block and immunohistochemistry,the detection rate of cell wax block+immunohistochemistry type was significantly higher.Through consistency analysis,the Kappa value of cell wax block+immunohistochemistry was 0.748(95%CI:0.697～0.802),which was significantly higher than that of single cell wax block and immunohistochemistry(χ2=13.903,P＜0.05).Conclusion:The cell wax block and immunohistochemistry can effectively distinguish the nature and type of serous cavity effusion,which is convenient to formulate targeted treatment measures in early clinical stage.
关键词
细胞蜡块/免疫组化/浆膜腔积液/定性诊断
Key words
Cell wax block/Immunohistochemistry/Effusion of serous cavity/Qualitative diagnosis
维普
万方数据