Screening of Key Targets and Mechanism for Colorectal Cancer Effects of Ginsenoside Rd Based on Network Pharmacology
Objective:To explore the molecular mechanism of ginsenoside Rd on colorectal cancer(CRC)by network pharmacology and molecular docking.Methods:Swiss Target Prediction database was used to screen the ginsenoside Rd targets.The targets of colon cancer were screened from GeneCards database and OMIM database,and the intersection targets were analyzed for functional enrichment and biological pathways.PPI network map was drawn by Cytoscape software,and molecular docking was conducted between the top 4 core targets and ginsenoside Rd.Results:Network pharmacological analysis showed that there were 44 key targets of ginsenoside Rd in the treatment of CRC.The results of the GO analysis showed that 2 046 biological processes(BP),48 cell components(CC)and 169 molecular functions(MF)were included.Molecular docking analysis of the top 4 hub genes with ginsenoside Rd demonstrated that ginsenoside Rd had effective energy for the key targets.Conclusion:MMP9.IL2,NR3C1,JUN,PTGS2,STAT3,PRSS1,F2RL1,CYP27B1 and F2 are the key targets of ginsenoside Rd in the treatment of colon cancer,which may inhibit colon cancer through PI3K/Akt signaling pathway,MAPK signaling pathway,Wnt signaling pathway,etc.It can be further verified by basic experiments.
万方数据
维普
