Effect of Toraputan and Neovtin for Elderly Refractory Heart Failure on Exercise Tolerance in Patients
Objective:To explore the effect of torvastan combined with neoactin on exercise tolerance in elderly patients with refractory heart failure.Methods:110 cases of elderly refractory heart failure treated in The First Affiliated Hospital of Henan University of Science and Technology from January to December 2022 were selected.They were divided into control group and study group with random number table method,with 55 cases in each group.Control group were treated with neovalin,and the study group were treated with tolvaptan and neovalin.The efficacy,cardiac function,serum index and cardiopulmonary exercise tests were evaluated between the two groups.Results:After 7 days of treatment,the total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(x2=4.274,P＜0.05).After 7 days of treatment,left ventricular ejection fraction(LVEF)increased in both groups,while left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)decreased in both groups.LVEF in the study group was higher than that in the control group,while LVEDD and LVESD were lower than that in the control group.The difference was statistically significant(t=4.935,4.339,2.708;P＜0.05).After 7 days of treatment,the N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)and procalcitonin(PCT)in both groups decreased,and the 6-min walking test(6 MWT)increased,and the NT-proBNP and PCT in the study group were lower than those in the control group,and higher than 6 MWT.The difference was statistically significant(t=9.370,7.596,3.370;P＜0.05).After 7 days of treatment,cardiopulmonary exercise test indexes increased in both groups,and the study group was higher than the control group,with statistically significant difference(t=4.753,5.668,2.669;P＜0.05).Conclusion:Tolvaptan and neovolin treatment in treating elderly refractory heart failure can improve cardiac function,relieve heart failure symptoms,and improve exercise tolerance.
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