摘要
目的:分析子痫前期发生胎儿生长受限(FGR)的危险因素.方法:回顾性分析2021年6月—2022年12月河南科技大学第二附属医院收治的125例子痫前期患者临床资料,将45例合并FGR的患者列为病例组,将80例未合并FGR的患者列为对照组,归纳可导致FGR的危险因素.结果:脐动脉舒张峰值流速比值(S/D)≥3、胎盘体积≤600 m3、胎盘重量≤500 g、胎盘系数≥2.0、游离脂肪酸(FFA)≥600 mmol/L、胰岛素样生长因子-1(IGF-1)≤100μg/L、抗血管紧张素Ⅱ1型受体自身抗体(AT1-AA)≥55 μg/mL、血清瘦素(LP)≥15ng/mL、血管内皮生长因子(VEGF)≤40 μg/mL、内皮素-1(ET-1)≥ 60 ng/L 为 FGR 的危险因素(OR=5.281、5.339、5.772、6.033、6.255、6.441、5.258、6.414、5.779、5.161).结论:低龄、BMI过低且合并宫内感染、胎儿脐动脉血流参数异常的子痫前期患者易发生FGR.
Abstract
Objective:To analyze the risk factors for FGR in preeclampsia.Methods:Retrospective analysis of clinical data of 125 patients with preeclampsia in the Second Affiliated Hospital of Henan University of Science and Technology from June 2021 to December 2022.45 patients with concomitant FGR were included in the case group,and 80 patients without concomitant FGR were included in the control group.Risk factors for FGR were summarized.Results:Umbilical artery S/D≥3,placental volume≤600 m3,placental weight≤500 g,placental coefficient ≥ 2.0,FFA≥600 mmol/L,IGF-1 ≤ 100 μg/L,AT1-AA≥55 pg/ml,LP≥15 ng/ml,VEGF≤40 pg/ml and ET-1≥60 ng/L were risk factors for FGR(OR=5.281,5.339,5.772,6.033,6.255,6.441,5.258,6.414.5.779,5.161).Conclusion:Preeclampsia patients with low age,low BMI combined with intrauterine infections and abnormal fetal umbilical artery blood flow parameters are prone to FGR.
维普
万方数据