Correlation Analysis of IFN-γ,D-D and CD4+/CD8+Levels in Peripheral Blood of Patients with Pulmonary Tuberculosis
Objective:To investigate the correlation between the levels of interferon-γ(IFN-γ),D-dimer(D-D)and CD4+/CD8+in peripheral blood of patients with pulmonary tuberculosis.Methods:115 patients with pulmonary tuberculosis admitted to the hospital from March 2020 to March 2023 were selected as the study group,and 1 15 healthy subjects in the same period were selected as the control group.According to the disease activity,the patients with tuberculosis were divided into active tuberculosis(72 cases)and inactive tuberculosis(43 cases).According to the severity of the disease,the patients with active tuberculosis were divided into mild tuberculosis(43 cases)and severe tuberculosis(29 cases).The levels of peripheral blood IFN-γ,D-D and CD4+/CD8+were compared between the two groups,patients with different disease activity and severity of disease at admission,and the correlation between peripheral blood IFN-γ,D-D and CD4+/CD8+levels at admission and tuberculosis,disease activity and severity of disease was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of combined detection of IFN-γ,D-D and CD4+/CD8+levels in peripheral blood on admission to hospital.Results:The levels of IFN-γ and D-D in peripheral blood of the study group were higher than those of the control group,and the levels of CD4+/CD8+were lower than those of the control group(t=36.373,34.110,23.504;P＜0.05).The levels of IFN-γ and D-D in peripheral blood of severe patients were higher than those of mild patients,and the levels of CD4+/CD8+were lower than those of mild patients(t=10.062,12.572,42.224;P＜0.05).At admission,the levels of IFN-γ and D-D in peripheral blood of patients in the severe group were higher than those in the mild group,and the levels of CD4+/CD8+in the severe group were lower than those in the mild group,with statistically significanct difference(t=7.237,11.421,7.311;P＜0.05).At admission,peripheral blood IFN-γ and D-D levels were positively correlated with tuberculosis,disease activity,and disease severity,while peripheral blood CD4+/CD8+levels were negatively correlated with tuberculosis,disease activity,and disease severity.The AUC of the combined diagnosis of severe pulmonary tuberculosis with peripheral blood IFN-γ,D-D and CD4+/CD8+levels was greater than that of each single indicator at admission.Conclusion:IFN-γ,D-D,CD4+/CD8+are involved in the occurrence and development of pulmonary tuberculosis,and have high efficacy in the diagnosis of pulmonary tuberculosis.
Pulmonary tuberculosisState of the diseaseInterferon-gammaD-dimerCD4+/CD8+
万方数据
维普
