Application of Remimazolam Combined Propofol in Elderly Patients Undergoing Analgesia Colonoscopy
Objective:To explore the efficacy of intravenous anesthesia with remimazolam combined propofol in elderly patients undergoing colonoscopy.Methods:A total of 120 elderly patients undergoing sedative colonoscopy were randomized into two groups:Group RP(remimazolam combined propofol)and Group P(propofol),with 60 patients in each group.RP group received remazolam 5 mg+propofol 0.5 mg/kg,and P group received propofol 1.0 mg/kg.MAP and HR of patients were monitored and recorded at 4 different time points:5 min before medication(T0),before admission after medication(T1),admission through liver area(T2),and being awake(T3).The colonoscopy time,waking time and adverse reactions,such as body movement,injection pain,respiratory depression,hiccup,nausea and vomiting,were compared between the two groups.Results:All cases completed the examination successfully,and there was no significant difference in the general information,colonoscopy time,recovery time and MAP of T0 time point between the two groups(P＞0.05).MAP at T1 and T2 was significantly lower than that at T0,and the decrease in RP group was smaller than that in P group,the difference was statistically significant(P＜0.05).At T3 time point,MAP of both groups recovered to T0 level,with no statistically significant difference(P＞0.05).The incidence of injection pain and respiratory depression in RP group was significantly lower than that in P group,with statistically significant difference(P＜0.05).The incidence of hiccup was significantly higher than that of group P,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of body movement,nausea and vomiting between the two groups(P＞0.05).Conclusion:RP may have non-inferior efficacy and a higher safety profile than propofol in elderly outpatients undergoing colonoscopy,so RP may be more suitable for elderly patients undergoing colonoscopy.
万方数据
维普
