Correlation Between Recurrent Respiratory Tract Infections and Intestinal Microecology in Children in Nanyang City
Objective:To analyze the correlation between clinical features and intestinal microecological status in children with recurrent respiratory tract infection(RRRI)in Nanyang City,and to provide reference for the prevention and treatment of RRRI.Methods:218 eligible children with recurrent respiratory tract infection in Hennan Children's Hospital were enrolled as the observation group,and 218 children who underwent physical examination in the same hospital were enrolled as the control group according to the ratio of 1∶1.Age,sex,feeding style,weight and height of all children were collected and compared.The infection site,infection frequency in a year and lymphocyte percentage(CD3+,CD4+and CD4+/CD8+)in the observation group were determined and sorted out.16S rRNA fluorescence quantitative PCR was used to detect the number of Bifidobacterium and Escherichia coli colonies in the intestinal tract of all children,and the B/E value was calculated and compared between groups.The bifidobacteria,Escherichia coli and B/E values of children with different infection sites,different infection frequencies and different lymphocyte percentage ranges were compared in the observation group.With B/E value＜1,the correlation between the infection site,different infection frequency,different lymphocyte percentage and intestinal microecological abnormalities in children with recurrent respiratory tract infection was analyzed.Results:The number of intestinal bifidobacterium colonies and B/E value of children in RRTI group were significantly lower than those in traditional group,and the number of E.coli was significantly higher than that in traditional group,with statistically significant difference(t=12.727,22.466,24.572;P＜0.05).The lower respiratory tract infection and the frequency of infection within 1 year were negatively correlated with intestinal microecological disturbance in children with RRTI(r=-0.621,-0.703).After treatment,CD3+and CD4+/CD8+in RRTI group were higher than those in traditional group,and CD4+were lower than those in traditional group,with statistically significant difference(t=5.312,4.799,4.424;P＜0.05).After treatment,the number of Escherichia coli and enterococcus in RRTI group was lower than that in traditional group,and the number of bifidobacterium was lower than that in traditional group,with statistically significant difference(t=5.874,6.031,8.192;P＜0.05).Conclusion:Respiratory tract infections in children in Zhengzhou City are highly correlated with intestinal microecological disturbance.The adjustment of intestinal microecological balance in children with recurrent respiratory tract infections should be paid close attention to,so as to improve the prevention and treatment efficiency of recurrent respiratory tract infections and promote children's health.
Repeated respiratory tract infection in childrenIntestinal microecological balanceBifidobacteriumEscherichia coliImmune functionCorrelationPrevention and treatment strategies
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