首页|染色质调节因子在肿瘤微环境中促进上皮性卵巢癌发生发展的研究进展

染色质调节因子在肿瘤微环境中促进上皮性卵巢癌发生发展的研究进展

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上皮性卵巢癌(EOCs)是卵巢癌最常见的病理类型之一,其发病机制复杂,预后较差,患者5年生存率不到40%,严重威胁了女性患者的生命健康,因此,需要寻找新的诊断标志物.染色质调节因子(CRs)是一类关键的蛋白质和非编码RNA分子,参与了调控基因表达、决定细胞命运以及肿瘤细胞与免疫细胞之间的相互作用等过程.近年来,越来越多的研究表明,染色质调节因子在上皮性卵巢癌肿瘤微环境(TME)中发挥重要作用.
Research Progress of the Development of Epithelial Ovarian Cancers with Chromatin Regulators in the Tumor Microenvironment
Epithelial ovarian cancer(EOCs)is one of the most common pathological types of ovarian cancer.Its pathogenesis is complex,the prognosis is poor,the 5-year survival rate of patients is less than 40%,and it seriously threatens the life and health of female patients.Therefore,it is necessary to find new diagnostic markers.Chromatin regulators(CRs)is key to protein and noncoding RNA molecules involved in regulating gene expression,cell fate decisions,and interactions between tumor cells and immune cells.In recent years,a growing body of research has shown that chromatin regulators play an important role in the tumor microenvironment of epithelial ovarian cancer.

Chromatin regulatorsEpithelial ovarian cancersTumor microenvironment

杨佳林、谢晓英

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赣南医科大学,江西 赣州 341000

赣南医科大学第一附属医院妇产科,江西 赣州 341000

染色质调控因子 上皮性卵巢癌 肿瘤微环境

2024

黑龙江医学
中华医学会黑龙江分会

黑龙江医学

影响因子:0.714
ISSN:1004-5775
年,卷(期):2024.48(20)