Distribution and Drug Resistance of Pathogenic Bacteria in ICU of a Tertiary Hospital in Guangxi
Objective:To analyze the distribution characteristics and drug resistance trends of pathogens isolated from the Intensive Care Unit(ICU)of The Fourth Affiliated Hospital of Guangxi Medical University from 2018 to 2022,in order to provide reference for anti infection treatment and hospital infection prevention and control of ICU patients in this region.Methods:A retrospective analysis was conducted on the distribution and drug sensitivity of pathogenic bacteria in the ICU of the hospital in each year.Results:Over the past 5 years,a total of 4 434 clinical isolates were collected,including 3 518 Gram negative bacteria(79.3％)and 916 Gram positive bacteria(20.7％).The detection rate of Acinetobacter baumannii always ranked first.The resistance rate of Escherichia coli to piperacillin/tazobactam has been increasing year by year,while the resistance rate to ceftriaxone and levofloxacin has been decreasing year by year.The resistance rate to carbapenems was relatively low.The resistance rate of Pseudomonas aeruginosa to ciprofloxacin was decreasing,and the average resistance rate to carbapenems was 19.2％for imipenem and 16.8％for meropenem,respectively.More than 80.0％of Acinetobacter baumannii showed a multidrug-resistant pattern.The detection rate of carbapenem resistant Klebsiella pneumoniae(CRKP)suddenly increased in 2022,from 0.6％in 2021 to 37.9％in 2022.Conclusion:ICU is a high-risk area for hospital infections.From 2018 to 2022,gram negative bacteria were the main pathogenic bacteria isolated in our hospital's ICU clinical practice.The detection rate of CRKP increased sharply in 2022,and the current situation of drug resistance is severe.Regular monitoring of pathogenic bacteria and their drug resistance trends is necessary,rational use of antibiotics,strengthening prevention and monitoring of hospital infections,and minimizing the cross transmission of multiple drug resistant bacteria.
Intensive Care UnitPathogenic bacteriaDrug resistanceMultiple drug resistance
万方数据
维普
