Relationship Between Disease Activity in Primary Sjogren's Syndrome and Serum TNF-α,IL-6 and IL-17 Levels
Objective:To explore the relationship between disease activity in primary Sjogren's syndrome(pSS)and serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-17(IL-17).Methods:A retrospective analysis was conducted on 96 patients with pSS admitted to the hospital from May 2021 to May 2023 as the pSS group.Additionally,96 healthy individuals who underwent physical examination in the hospital during the same period were selected as the healthy control group.Serum TNF-α,IL-6 and IL-17 levels of pSS group and the healthy control group were measured and compared.And 96 patients were divided into the pSS active group(38 cases,ESSDAI score≥5 points)and the pSS stable group(58 cases,ESSDAI score＜5 points)based on the Disease Activity Index of Sjogren's Syndrome(ESSDAI).Serum TNF-α,IL-6,IL-17 and ESSDAI scores were evaluated using Pearson correlation analysis.Results:Serum TNF-α,IL-6 and IL-17 were significantly higher than those of the healthy control group,and the differences were statistically significant(t=19.787,25.663,25.400;P＜0.05).Serum TNF-α,IL-6 and IL-17,as well as the ESSDAI score,of pSS group were significantly higher than those in pSS stable group,and the differences were statistically significant(t=8.286,5.865,6.470,14.920;P＜0.05).Pearson correlation analysis showed that the ESSDAI score of pSS patients was correlated with serum TNF-α,IL-6 and IL-17(r＞0,P＜0.05).Conclusion:ESSDAI score and serum TNF-α,IL-6 and IL-17 are both positively correlated,and can serve as important serum biomarkers to assist in evaluating disease activity in pSS patients.
万方数据
维普
