Research Progress of m6A RNA Methylation Modification in Head and Neck Squamous Cell Carcinoma
The mechanism and the vital roles of m6A in head and neck squamous cell carcinoma pathogenesis and progression are indrodiced.These modifications of m6A in HNSCC,a number of ones appear to have an oncogenic role,while others play a tumor-suppressor role.The study reviews that the recent research progress of RNA N6-methyladenosine methylation in HNSCC.The methylation modification regulatory factors found in NPC are METTL3,YTHDF3 and IGF2BP1;which in HPSCC are YTHDF1,ALKBH5 and METTL3.In LSCC,they are IGF2BP2,IGF2BP3 and ALKBH5,while in OSCC,they are METTL14,ALKBH5,and HNRNPC,etc.
N6-methyladenosineMethylationHead and neck squamous cell carcinomaResearch progress
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维普
