Correlation Between 99mTc-MDP Bone Imaging Parameters and Bone Mineral Density in Patients with Tumor Bone Metastases
Objective:To investigate and analyze the correlation between semi-quantitative parameters of bone metabolism and bone mineral density on 99mTc-methylene diphosphate(MDP)bone imaging in patients with tumor bone metastases.Methods:The study retrospectively analyzed 168 patients with bone metastases of malignant tumors in the hospital from January 2021 to December 2022.The value of bone imaging for the diagnosis of osteoporosis was determined,and the correlation between semiquantitative parameters of bone metabolism in bone imaging and bone mineral density was analyzed.Results:Among 168 patients,68 cases were judged to be osteoporotic by bone density(osteoporosis group).The lumbar spine/femoral stem ROI ratio and the femoral neck/femoral stem ROI ratio in the osteoporosis group were higher than those in the non-osteoporosis group(t=12.575,14.015;P＜0.05).The bone density of lumbar vertebrae and femoral neck in the osteoporosis group was significantly lower than that in the non-osteoporosis group,and the difference was statistically significant(t=12.575,11.199;P＜0.05).In patients with osteoporosis with tumor bone metastasis,Pearson analysis showed that lumbar/femoral shaft ROI ratio,femoral neck/femoral shaft ROI ratio were negatively correlated with lumbar bone density and femoral neck bone density(r=-0.789,-0.697,-0.706,-0.745;P＜0.05).Conclusion:Semi-quantitative parameters of bone metabolism in 99mTc-MDP bone imaging in osteoporosis patients with bone metastases from malignant tumors correlate better with bone density.The diagnosis of osteoporosis has a high sensitivity.It has certain predictive significance and application value for tumor patients with combined osteoporosis during follow-up.
Malignant tumor bone metastasisOsteoporosis99mTc methylene diphosphateBone imagingBone densityRelativity
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