Effect of Recombinant Human Brain Natriuretic Peptide Assisted Emergency PCI for Acute Heart Failure
Objective:To observe the effect of recombinant human brain natriuretic peptide(rhBNP)assisted emergency percutaneous coronary intervention(PCI)in acute heart failure and its impact on patient prognosis.Methods:106 patients with acute heart failure were randomly divided into observation group and control group,with 53 patients in each group.Control group only received emergency PCI treatment,while observation group received rhBNP assisted emergency PCI treatment.The improvement of vascular endothelial function,myocardial injury,cardiac function,as well as the occurrence of cardiovascular adverse events(MACE)and drug-related adverse reactions were compared between the two groups.Results:After treatment,6-kelo-PGF1 in the observation group α was higher than the control group,ET-1,NO,LDH,CK-MB and CTnⅠ were all lower than the control group.LVEF was higher than the control group,while LVDD was lower than the control group.The incidence of MACE was lower than that of the control group,and the differences were statistically significant(t=3.522,3.111,2.930,2.814,3.138,3.686,3.468,3.793;x2=6.481;P＜0.05).There was no statistically significant difference in the incidence of drug-related adverse reactions between the two groups(x2=0.166,P＞0.05).Conclusion:The combination of rhBNP and emergency PCI in the treatment of acute heart failure can effectively reduce vascular endothelial and myocardial damage,improve cardiac function,avoid ventricular remodeling,and reduce the risk of MACE in patients.There is no significant increase in the risk of adverse drug reactions,and the safety is relatively high
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维普
