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自发性蛛网膜下腔出血后的病理生理机制及治疗靶点

Pathophysiology and Therapeutic Target of Spontaneous Subarachnoid After Hemorrhage and Therapeutic Targets

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自发性蛛网膜下腔出血(aSAH)是一种常见的出血性脑卒中疾病,患者的预后具有较高的致残率,病死率,为社会和家庭带来了严重的负担.出血后的病理生理机制十分复杂,可导致神经细胞水肿、血脑屏障通透性改变、脑血管痉挛等改变.大量的基础实验研究发现,血液毒性作用、炎性病变、线粒体死亡、自由基释放均参与了该变化过程.本研究阐述了 aSAH后的病理生理机制及凋亡途径,为治疗aSAH患者提供潜在的靶点或策略.
Spontaneous subarachnoid hemorrhage is a common hemorrhagic stroke disease,which has a high disability rate and mortality rate,bringing significant burden to society and families.The post-hemorrhage physiological mechanisms are complex,leading to changes such as neuronal edema,blood-brain barrier permeability alteration,and cerebral vasospasm.Extensive basic experimental studies have found that blood toxicity,inflammatory lesions,mitochondrial death,and free radical release all participate in this process of change.The study elucidates the pathological physiological mechanisms and apoptotic pathways after spontaneous subarachnoid hemorrhage to provide potential targets or strategies for treating patients with subarachnoid hemorrhage.

Spontaneous subarachnoid hemorrhageApoptosisPhysiological and physiological mechanisms diseaseTreatment

蔡阳阳、孟凡学

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开封市人民医院神经外科,河南 开封 475000

自发性蛛网膜下腔出血 凋亡 病理生理机制 治疗

2024

黑龙江医学
中华医学会黑龙江分会

黑龙江医学

影响因子:0.714
ISSN:1004-5775
年,卷(期):2024.48(24)