首页|妊娠期和产褥期VTE的防治研究

妊娠期和产褥期VTE的防治研究

扫码查看
目的:妊娠期和产褥期静脉血栓栓塞症(VTE)的防治研究.方法:回顾性分析我院2021 年 11 月至2023 年5 月我院分娩的产妇 160 例,根据VTE评分,将评分>2 分孕产妇分成A组54 例、B组53 例、C组53 例,A组使用低分子肝素联合下肢气压治疗预防,B组采取双下肢脉冲式动静脉气压治疗(ICPD)预防,C组拒绝采取预防措施;对3 组患者血栓前标志物、凝血指标、生活质量进行比较.结果:A组抗凝血酶Ⅲ(AT-Ⅲ)、血浆蛋白C(PC)、蛋白S(PS)水平较B、C组高,D-二聚体(D-D)较B、C组低(P<0.05);A组血浆凝血酶原时间(PT)、活化部分凝血活酶原时间(aPTT)、纤维蛋白原(Fbg)水平较B、C组低,凝血酶时间(TT)水平较B、C组高(P<0.05);A组WHO生活质量量表(WHOQOL-BREF)各维度评分较B、C组高(P<0.05).结论:科学有效的妊娠期和产褥期VTE的防治措施可有效改善血栓前标志物、凝血指标水平,降低VTE发生的风险,进而提高生活质量,值得推广.
Prevention and Treatment of VTE During Pregnancy and Puerperal Period
Objective:To study the prevention and treatment of VTE during pregnancy and puerperal period.Methods:A retrospective analysis was performed on 160 parturient women who gave birth in our hospital from November 2021 to May 2023. According to the VTE score,the parturient women with scores >2 were divided into group A (54 cases),group B (53 cases)and group C (53 cases).Group A was treated with low molecular weight heparin combined with lower extremity pressure for treatment and prevention.Group B was treated with pulsed arteriovenous barotherapy (ICPD),group C refused to take any preventive measures. The pre-thrombotic markers,coagulation indexes and quality of life were compared between the three groups.Results:The levels of antithrombin Ⅲ(AT-Ⅲ),plasma protein C (PC),and protein S (PS)in group A were higher than those in groups B and C,while D-dimer (D-D)was lower than those in groups B and C (P<0.05 );The plasma prothrombin time (PT),activated partial thromboplastin time (aPTT),and fibrinogen (Fbg)levels in group A were lower than those in groups B and C,while the thrombin time (TT)levels were higher than those in groups B and C (P<0.05);The WHO Quality of Life Scale (WHOQOL-BREF)scores in all dimensions in Group A were higher than those in Groups B and C (P<0.05).Conclusion:Scientific and effective prevention and treatment of VTE during pregnancy and puerperal period can effectively improve the level of pre-thrombotic markers and coagulation indexes,reduce the risk of VTE occurrence,and then improve the quality of life,which is worth promoting.

Prethrombotic MarkersCoagulation IndexIncidence of VTEQuality of Life

曾宇雅、谢清娥、陈雁辉

展开 >

梅州市妇幼保健院(广东 梅州 514000)

血栓前标志物 凝血指标 VTE发生率 生活质量

梅州市社会发展科技计划项目

2022C0301090

2024

黑龙江医药
黑龙江省药品审评认证中心

黑龙江医药

影响因子:0.597
ISSN:1006-2882
年,卷(期):2024.37(1)
  • 8