Objective:To investigate the significance of detecting 25 hydroxyvitamin D,hypersensitive C-reactive protein (hs- CRP)and estimated glomerular filtration rate in patients with brain atrophy and their predictive value.Methods:155 patients with brain atrophy aged ≥50 years (observation group)and 134 healthy people aged ≥50 years (control group)were retrospectively analyzed.25 hydroxyvitamin D,hs-CRP and estimated glomerular filtration rate were detected respectively in two groups,and the predictive value of detection indexes on brain atrophy was analyzed.Results:The 25 hydroxyvitamin D and estimated glomerular filtration rate in observation group were lower than those in control group,and hs-CRP was higher than that in control group (P<0. 05).The AUC of the area under the curve in the diagnosis of brain atrophy by combined detection was better than that by the three indexes alone (P<0.05).The combined determination of 25 hydroxyvitamin D,hs-CRP and estimated glomerular filtration rate was more effective in diagnosing brain atrophy than the three indexes alone (P<0.05).All the indexes were closely correlated with brain atrophy (P<0.05).Conclusion:25 hydroxyvitamin D,estimated glomerular filtration and hs-CRP are related to the occurrence and development of brain atrophy in middle-aged and elderly people,and have a certain predictability.Clinical combined detection of these indicators can provide a certain help for early detection and intervention of brain atrophy.
Cerebral atrophy25 Hydroxyvitamin DHs-CRPEstimated glomerular filtration rateDetection value
维普
万方数据
