Impact of HPV Vaccination after Cervical LEEP Surgery on the Prognosis of Patients with Cervical Intraepithelial Neoplasia
Objective:To explore the impact of postoperative administration of human papillomavirus(HPV)vaccine on the prognosis of cervical intraepithelial neoplasia(CIN)patients after cervical circular resection(LEEP).Methods:76 CIN patients admitted to Xinfeng County People's Hospital in Jiangxi Province from June 2019 to June 2021 were selected.A random number table method was established using Excel spreadsheets to group them.38 patients in the observation group and 38 patients in the control group received LEEP surgery.The observation group received bivalent HPV vaccine according to the 0/2/6 program after surgery,while the control group did not receive HPV vaccine after surgery.Compare the changes in HPV positivity rate,postoperative CIN re-currence,and quality of life between two groups of patients.Results:The comparison of HPV positivity rates between the two groups at 6 months after surgery and 3 months,6 months,and 12 months after vaccination completion showed that the observation group was lower than the control group(P＜0.05).The comparison of CIN recurrence rates between the two groups at 12,15,and 18 months after surgery showed that the observation group had lower rates than the control group(P＜0.05).The scores of the Quality of Life Scale(SF-36)increased in both groups after surgery compared to before,and the observation group had a more significant increase in postoperative scores(P＜0.05).Conclusion:Postoperative administration of bivalent HPV vaccine to CIN patients after LEEP can reduce postoperative HPV positivity and CIN recurrence rates,improve quality of life,and bring good news to patients.It is worth promoting.
万方数据
维普
