首页|乙酰半胱氨酸颗粒联合药学干预治疗儿童下呼吸道感染的有效性分析

乙酰半胱氨酸颗粒联合药学干预治疗儿童下呼吸道感染的有效性分析

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目的:探讨乙酰半胱氨酸颗粒与药学干预联合治疗儿童下呼吸道感染(LRTI)的疗效.方法:选择我院2022年1月—2024年2月收治的60例LRTI患儿,按随机数字表法分为两组.两组均行常规抗病毒治疗.对照组(30例)予以乙酰半胱氨酸颗粒进行治疗,观察组(30例)在对照组基础上联合药学干预,两组均持续观察1周.对比两组临床疗效、恢复进程、血清炎症因子指标[C反应蛋白(CRP)、白细胞计数(WBC)]及不良反应.结果:观察组临床总有效率高于对照组,临床症状消退时间均短于对照组(P<0.05);相较于治疗后对照组,观察组CRP、WBC水平均较低(P<0.05);观察组不良反应发生率低于对照组(P<0.05).结论:乙酰半胱氨酸颗粒联合药学干预在儿童LRTI的治疗中疗效显著,可有效促进临床症状恢复,降低血清炎症因子指标水平,还可提升用药安全性.
Effectiveness Analysis of Acetylcysteine Granules Combined with Pharmaceutical Intervention in the Treatment of Lower Respiratory Tract Infections in Children
Objective:To explore the efficacy of combining acetylcysteine particles and pharmaceutical intervention in the treatment of pediatric lower respiratory tract infection(LRTI).Methods:Sixty children with LRTI admitted to our hospital from January 2022 to February 2024 were randomly divided into two groups using a random number table method.Both groups received routine antiviral treatment.The control group(30 cases)was treated with acetylcysteine granules,while the observation group(30 cases)received pharmaceutical intervention in combination with the control group.Both groups were continuously observed for one week.Compare the clinical efficacy,recovery process,serum inflammatory cytokine markers[C-reactive protein(CRP),white blood cell count(WBC)],and adverse reactions between two groups.Results:The total clinical effective rate of the observation group was higher than that of the control group,and the time for clinical symptom resolution was shorter than that of the control group(P<0.05);Compared with the control group after treatment,the observation group had lower levels of CRP and WBC(P<0.05);The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:The combination of acetylcysteine granules and pharmaceutical intervention has a significant therapeutic effect in the treatment of lower respiratory tract infections in children.It can effectively promote clinical symptom recovery,reduce serum inflammatory factor levels,and also improve medication safety.

Lower respiratory tract infectionAcetylcysteine granulesPharmaceutical interventionClinical efficacyRecovery processInflammatory factors

郑录敏、吴洁琼、黄勤俊、石景瑜

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上饶市广信区人民医院(江西上饶 334100)

下呼吸道感染 乙酰半胱氨酸颗粒 药学干预 临床疗效 恢复进程 炎症因子

2023年江西省上饶市第二批科技计划项目

2023CZDX201

2024

黑龙江医药
黑龙江省药品审评认证中心

黑龙江医药

影响因子:0.597
ISSN:1006-2882
年,卷(期):2024.37(5)