首页|胃镜微创与胃镜联合腹腔镜治疗胃间质瘤的临床疗效与安全性对比研究

胃镜微创与胃镜联合腹腔镜治疗胃间质瘤的临床疗效与安全性对比研究

Clinical Efficacy and Safety of Minimally Invasive and Combined Laparoscopic Gastroscopy in the Treatment of Gastric Stromal Tumor

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目的:对比胃镜微创与胃镜联合腹腔镜治疗胃间质瘤的临床疗效与安全性.方法:研究回顾性纳入医院2018年3月—2023年3月临床收治胃间质瘤患者86例为对象,按照患者不同治疗术式将其划分为胃镜微创组(n=40)与胃镜联合腹腔镜组(n=46),对比不同治疗模式下组间疗效、安全性、炎性因子[C反应蛋白(CRP)、白细胞(WBC)]及术后随访结果.结果:胃镜联合腹腔镜组手术时间长于胃镜微创组,肿瘤切除率高于胃镜微创组(P<0.05),胃镜联合腹腔镜组与胃镜微创组术中出血量、住院时间及术后排气时间无统计学差异(P>0.05);胃镜联合腹腔镜组与胃镜微创组并发症发生率无统计学差异(P>0.05);胃镜联合腹腔镜组与胃镜微创组术前炎性因子(WBC、CRP)无统计学意义(P>0.05),术后1天、术后3天两组炎性因子同术前比较,呈先上升、后下降趋势(P<0.05),胃镜微创组术后1天炎性因子水平低于胃镜联合腹腔镜组(P<0.05),术后3天组间炎性因子水平无统计学意义(P>0.05);胃镜联合腹腔镜组与胃镜微创组随访生存率无统计学意义(P>0.05),胃镜联合腹腔镜组随访疾病复发率低于胃镜微创组(P<0.05).结论:胃镜微创与胃镜联合腹腔镜治疗安全性均较高,但胃镜微创术后早期炎性因子水平更低,胃镜联合腹腔镜能提升临床胃间质瘤肿瘤切除率,降低疾病复发率.
Objective:To compare the clinical efficacy and safety of minimally gastroscopy and laparoscopy for gastric stromal tumor.Methods:Study in the hospital from March 2018 to March 2023,86 patients,which were divided into minimally invasive(n=40)and laparoscopic(n=46),safety,inflammatory factor[C reactive protein(CRP),white ocytes(WBC)]and postoperative follow-up results.Results:The operation time of gastroscopy and laparoscopic group was longer than that of gastroscopy and minimally invasive group,The tumor resection rate was higher than that in the endoscopic minimally invasive group(P<0.05),There was no statistical difference in intraoperative bleeding,hospitalization time and postoperative exhaust time between gastroscopy and laparoscopy group and minimally invasive gastroscopy group(P>0.05);There was no significant difference in the complication rate between the gastroscopy and minimally invasive gastroscopy groups(P>0.05);No significant inflammatory factors(WBC,CRP)before gastroscopy and laparoscopy(P>0.05),Compared with the two groups of inflammatory factors at 1 day after surgery and 3 days before surgery,The trend of rising first and decreasing later(P<0.05),The inflammatory factor level in the first day was lower than that in the gastroscopy and laparoscopy group(P<0.05),No significant levels of inflammatory factors between 3 days after surgery(P>0.05);The follow-up survival rate between gastroscopy and gastroscopy was not significant(P>0.05),The follow-up disease recurrence rate in the gastroscopy and laparoscopic group was lower than that in the gastroscopy minimally invasive group(P<0.05).Conclusion:The safety of minimally invasive treatment of gastroscopy and gastroscopy is high,but the level of inflammatory factors in the early stage after minimally invasive gastroscopy is lower.Gastroscopy and laparoscopy can improve the tumor resection rate of clinical gastric stromal tumor and reduce the disease recurrence rate.

Gastroscopy minimally invasiveGastroscopy combined with laparoscopyGastric stromal tumorSafetyEfficacy

林铭华、兰禄英、叶文

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福建医科大学附属龙岩第一医院消化内科&消化内镜(福建龙岩 364000)

福建省龙岩市第二医院医务处(福建龙岩 364000)

福建医科大学附属龙岩第一医院 胃肠外科(福建龙岩 364000)

胃镜微创 胃镜联合腹腔镜 胃间质瘤 安全性 疗效

龙岩市科学技术项目

2023LYF17028

2024

黑龙江医药
黑龙江省药品审评认证中心

黑龙江医药

影响因子:0.597
ISSN:1006-2882
年,卷(期):2024.37(5)
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