Efficacy and Safety Analysis of Butorphanol Combined with Dexmedetomidine in the Treatment of Patients with Acute Stroke Undergoing Mechanical Thrombectomy under Non-Intubated General Anesthesia
Objective:To analyze the efficacy of butorphanol combined with dexmedetomidine in mechanical thrombectomy of patients with acute stroke(CS)under non-intubation general anesthesia.Methods:From June 2022 to June 2024,60 patients treated with CS mechanical thrombectomy under non-intubation general anesthesia were selected and randomly divided into two groups(30 cases in each group).The control group received dexmedetomidine non-intubation general anesthesia,and the observation group received butorphanol combined with dexmedetomidine non-intubation general anesthesia.Hemodynamics,sedative and analgesic effects,quality of recovery and adverse reactions were compared between the two groups.Results:The heart rate and mean arterial pressure of observation group were lower than control group 5min after anesthesia and after operation.At 2h,6h and 12h after surgery,the visual analogue pain score of the observation group was lower than that of the control group,and the Ramsay sedation score was higher than that of the control group.In the observation group,the respiratory recovery time was(6.35±1.26)min,the waking time was(16.83±1.56)min,and the extubation time was(10.26±1.34)min.It was shorter than that of control group(8.31±1.69)min,(20.45±2.33)min,(13.52±1.98)min(P＜0.05).There was no difference in adverse reactions between the two groups(P＞0.05).Conclusion:Butorphanol combined with dexmedetomidine can achieve good sedative and analgesic effects,maintain the he-modynamic stability of patients undergoing CS mechanical thrombectomy under non-intubation general anesthesia,and help patients recover after surgery without serious adverse reactions,which is worthy of clinical promotion and application.
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维普
