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缺血性脑卒中患者发生脑小血管病的危险因素分析

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目的:探究缺血性脑卒中患者合并脑小血管病的危险因素.方法:回顾性选取研究对象300例于我院收治的缺血性脑卒中患者的临床资料,分为合并脑小血管病组(n=215例)和未合并脑小血管病组(n=85例),分组依据患者是否发生脑小血管病,选例时间2020年2月至2023年2月.收集所有患者的临床资料,统计两组预后情况,采用多因素Logistic回归分析法分析发生脑小血管病(缺血性脑卒中患者)的危险因素.结果:单因素、多因素Logistic回归分析结果显示,年龄大、合并高血压、合并糖尿病、血清同型半胱氨酸(HCY)、尿酸(UA)水平高均为影响脑小血管病患者发生缺血性脑卒中的独立危险因素(OR=2.192、2.321、2.145、2.487、2.168,P<0.05).两组患者美国国立卫生院卒中量表(NIHSS评分入院第7天显著低于降低入院时(P<0.05);且组间比较,合并脑小血管病组入院后第7天NIHSS评分、治疗后90天改良Rankin评分(mRS评分)也高于未合并脑小血管病组(P<0.05).结论:相对于缺血性脑卒中患者,缺血性脑卒中并发脑小血管病患者的预后较差,年龄大、合并高血压、合并糖尿病、血清HCY水平高、UA水平高均为影响脑小血管病发生缺血性脑卒中的独立危险因素,因此临床可根据上述结论给予缺血性脑卒中合并脑小血管病患者针对性预防和治疗措施,以降低患者发生缺血性脑卒中的风险.
Analysis of Risk Factors of Small Cerebral Vascular Disease in Patients with Ischemic Stroke
Objective:To explore the risk factors of small cerebral vascular disease in patients with ischemic stroke.Methods:The clinical data of 300 patients with ischemic stroke admitted to our hospital were retrospectively selected and divided into two groups(n=215 cases)with and without small cerebral vascular disease(n=85 cases).The groups were divided according to whether the patients had small cerebral vascular disease,and the cases were selected from February 2020 to February 2023.The clinical data of all patients were collected,and the prognosis of the two groups was analyzed by multivariate Logistic regression analysis.The risk factors of small cerebral vascular disease(patients with ischemic stroke)were analyzed.Results:Univariate and multivariate Logistic regression analysis showed that Age,hypertension,diabetes,and high serum homocysteine(HCY)and uric acid(UA)levels were independent risk factors for ischemic stroke in patients with small cerebral vascular disease(OR=2.192,2.321,2.145,2.487,2.168,P<0.05).Two groups of patients had significantly lower NIHSS scores on the 7th day of admission compared to those at reduced admission(P<0.05)on the National Institutes of Health Stroke Scale;And compared between groups,the NIHSS score on the 7th day after admission and the modified Rankin score(mRS score)on the 90th day after treatment in the group with concomitant cerebral small vessel disease were also higher than those in the group without concomitant cerebral small vessel disease(P<0.05).Conclusion:Compared with patients with ischemic stroke,the prognosis of patients with ischemic stroke complicated with small cerebral vascular disease is worse.Older age,complicated with hypertension,complicated with diabetes,and high serum HCY and UA levels are independent risk factors for ischemic stroke.Therefore,according to the above conclusions,targeted prevention and treatment measures can be given to patients with ischemic stroke complicated with small cerebral vascular disease to reduce the risk of ischemic stroke.

Ischemic strokeSmall cerebral vascular diseaseSingle factorRisk factorPrognosis

刘芬、陈名峰

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福建省立医院神经内科(福建 福州 350000)

缺血性脑卒中 脑小血管病 单因素 危险因素 预后

2024

黑龙江医药
黑龙江省药品审评认证中心

黑龙江医药

影响因子:0.597
ISSN:1006-2882
年,卷(期):2024.37(6)