首页|益智通窍汤联合参附注射液对脑梗死患者轻度认知障碍的影响

益智通窍汤联合参附注射液对脑梗死患者轻度认知障碍的影响

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目的:探究益智通窍汤联合参附注射液对脑梗死患者轻度认知障碍的影响.方法:收集湛江中心人民医院在2023年1月—2024年3月住院诊疗的96例脑梗死患者临床资料,利用电脑数字表法随机分为治疗组与参照组,各48例.其中参照组接受参附注射液治疗,治疗组基于参照组方案联用益智通窍汤.持续治疗10天,比较两组临床疗效及安全性;治疗前后血清胱抑素C(Cys-C)、谷氨酸(Glu)水平、认知功能(MoCA)评分及日常生活活动能力(ADL)评分.结果:相比参照组,治疗组疗效有效率、安全性更高(P<0.05);相比治疗前,两组血清Cys-C、Glu水平治疗后均下降,MoCA评分与ADL评分治疗后均升高,且治疗组改善幅度高于参照组(P<0.05).结论:脑梗死患者经益智通窍汤联合参附注射液后认知障碍明显改善,且利于降低血清Cys-C、Glu水平,辅助改善日常生活活动能力,安全性高,值得推广.
Effect of Yizyitongqiao Decoction Combined with Shenfu Injection on Mild Cognitive Impairment in Patients with Cerebral Infarction
Objective:To explore the effects of Yizyitongqiao Decoction combined with Shenfu injection on mild cognitive impairment in patients with cerebral infarction.Methods:96 cases of cerebral infarction patients hospitalized in Zhanjiang Central People's Hospital from January 2023 to March 2024 were collected and randomly divided into treatment group and reference group with 48 cases in each group by computer digital table method.The reference group was treated with Shenfu injection,and the treatment group was treated with Yizhouqiao decoction based on the plan of the reference group.After continuous treatment for 10 days,the clinical efficacy and safety of the two groups were compared.Serum cystatin C(Cys-C),glutamate(Glu)levels,cognitive function(MoCA)scores and activities of daily living(ADL)scores before and after treatment.Results:Compared with the reference group,the efficacy and safety of the treatment group were higher(P<0.05).Compared with before treatment,serum Cys-C and Glu levels in both groups were decreased after treatment,MoCA score and ADL score were increased after treatment,and the improvement rate in the treatment group was higher than that in the reference group(P<0.05).Conclusion:The cognitive impairment of cerebral infarction patients was significantly improved after Yidongqiao Decoction combined with Shenfu injection,and it was beneficial to reduce the levels of serum Cys-C and Glu,and assisted to improve the ability of daily living activities,which was safe and worthy of promotion.

Cerebral InfarctionPuzzle DecoctionShenfu InjectionCognitive ImpairmentBalancing Function

李丽丝、陈戈

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湛江中心人民医院康复医学科(广东湛江 524045)

湛江中心人民医院神经内三科(广东湛江 524045)

脑梗死 益智通窍汤 参附注射液 认知障碍 平衡功能

2024

黑龙江医药
黑龙江省药品审评认证中心

黑龙江医药

影响因子:0.597
ISSN:1006-2882
年,卷(期):2024.37(6)