Monitoring Results of Hepatitis B Vaccine in 363 Healthy Children Aged 3 to 7 Years
Objective:To explore and analyze the monitoring results of hepatitis B vaccine in 363 healthy children aged 3 to 7 years.Methods:363 healthy children who received antibody examination in Nanchang Qingshanhu district for Disease Control and Prevention from May 2021 to December 2023 were collected as observation objects,including180 boys and183 girls,with an average age of(5.05±0.45)years.All of them have completed 3 rounds of hepatitis B vaccine immunization(0-January-June).Two and a half pairs of hepatitis B virus surface antigen(HBsAg),hepatitis B virus surface antibody(HBsAb),hepatitis B virus E antigen(HBeAg),hepatitis B virus core antibody(HBcAb),and hepatitis B virus E antibody(HBeAb)were tested.The positive rates of HBsAb in healthy children of different ages and genders were analyzed.The positive rate of HBsAb in different years after vaccination in healthy children of different genders was analyzed.Results:There was a significant difference in the HBsAb positive rate between healthy children of different ages after the third dose of vaccination(P＜0.05).The HBsAb positive rate of 3-year-old children after the third dose of vaccination was higher than that of 4,5,6,and 7 years old children(P＜0.05).The HBsAb positive rate of 4-year-old children after the third dose of vaccination was higher than that of 6-year-old and 7-year-old children(P＜0.05).The HBsAb positive rate in 5-year-old children was significantly higher than that in 7-year-old children after the third dose of vaccination(P＜0.05).Among 363 healthy children,there was no significant difference in the HBsAb positive rate between boys and girls after vaccination(P＞0.05).The highest HBsAb positive rate was 91.18％in 3-year-old girls and the lowest was 36.67％in 7-year-old girls.The highest HBsAb positive rate was 85.29％in 3-year-old boys and the lowest was 36.67％in 7-year-old boys.The HBsAb positive rate of boys and girls decreased with the increase of age,and the difference was statistically significant(P＜0.05).Conclusion:Healthy children aged 3 to 7 years old produce a certain degree of HbsAb antibody after vaccination with hepatitis B vaccine,and the analysis found that the HBsAb positive rate was closely related to the age of children and vaccination years,but it was not related to the gender of the children.The HBsAb positive rate may decrease with the increase of vaccination years,and it is necessary to strengthen immunization combined with the actual situation of children's antibodies to improve the HBsAb positive rate.
Hepatitis B VaccineChildrenVaccinationAntibody MonitoringResult
万方数据
维普
