Application Value of ESR,White Blood Cell Count and CRP in Clinical Diagnosis of Senile Knee Arthritis
Objective:To explore the value of combined detection of erythrocyte sedimentation rate(ESR),white blood cell count(WBC)and C-reactive protein(CRP)in the clinical diagnosis of elderly knee osteoarthritis(KOA).Methods:105 elderly patients with KOA who received treatment in our department of Orthopedics from January 2023 to July 2024 were collected as experimental subjects.In the same period,45 volunteers who received health examination in our hospital were collected as the reference group.ESR,WBC and CRP were all tested.Kellgren-Lawrence(K-L)grades were applied to test group,with grade 1 and 2 as mild group,grade 3 as moderate group,and grade 4 as severe group.The levels of ESR,WBC and CRP were compared between the two groups.The levels of ESR,WBC and CRP in patients with different severity were compared.The diagnostic efficiency of ESR,WBC and CRP was analyzed by ROC curve.Results:Compared with the control group,the levels of ESR,WBC and CRP in experimental group were significantly higher(P＜0.05).Compared with mild group,ESR,WBC and CRP levels in moderate and severe group were higher,and ESR,WBC and CRP levels in severe group were higher than those in moderate group(P＜0.05).When WBC≥10.55×109/L,the di-agnostic sensitivity was 80.18％and the specificity was 58.97％.When ESR ≥22.15mm/h,the diagnostic sensitivity was 76.03％and the specificity was 55.17％.When CRP≥15.17mg/L,the diagnostic sensitivity was 88.07％and the specificity was 78.05％.The AUC of ESR,WBC and CRP combined diagnosis was 0.928,the diagnostic sensitivity was 97.14％,and the specificity was 93.33％.Conclusion:The levels of ESR,WBC and CRP in elderly patients with KOA are higher,and the combined detection of these three indicators has a higher diagnostic efficacy.It is speculated that ESR,WBC and CRP can be used as auxiliary and reliable indicators for the primary diagnosis of KOA in elderly patients.
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