Correlation analysis and clinical value of echocardiographic parameters and serum hs-CRP level with short-term prognosis in patients with chronic heart failure
Objective:To analyze the correlation and clinical value of echocardiographic parameters[left ven-tricular end-diastolic diameter(LVEDD),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)]and serum high-sensitivity C-reactive protein(hs-CRP)levels with the short-term prognosis of patients with chronic heart failure.Methods:115 pa-tients with chronic heart failure in the Third People's Hospital of Jiyuan City from July 2021 to September 2023 were enrolled as the study group,and 115 healthy individuals during the same period were served as the control group.Patients in the study group were further divided into good prognosis and poor prognosis subgroups based on their re-cent prognosis.The echocardiographic parameters and serum hs-CRP levels upon admission were compared be-tween the two groups and between patients with different prognoses.Partial regression analysis was performed to as-sess the association between echocardiographic parameters,serum hs-CRP levels and the prognosis of chronic heart failure.Additionally,the predictive value of these factors for poor prognosis in chronic heart failure patients was an-alyzed.Results:The study group exhibited lower LVEF and LVEDV echocardiographic parameters[(46.28±5.41)％,(46.36±3.19)mm]compared to the control group[(67.94±6.62)％,(82.49±4.52)mm],while LVEDD,LVESD,and serum hs-CRP parameters[(55.67±4.33)mm,(46.04±3.77)mm,(10.57±2.11)mg/L]were higher,with statistically significant differences(P＜0.05).Patients with poor prognosis had lower LVEF and LVEDV[(40.16±3.41)％,(44.16±2.17)mm]and higher LVEDD,LVESD and serum hs-CRP parameters[(61.51±2.24)mm,(50.16±3.49)mm,(19.84±2.37)mg/L]compared to those with good prognosis[(49.67±4.16％),(50.33±2.55)mm;(52.44±2.77)mm,(43.76±3.31)mm,(5.44±3.34)mg/L],with statistically significant differences(P＜0.05).Upon admission,LVEDD,LVESD and serum hs-CRP parameters were identified as risk factors for poor prognosis,while LVEF and LVEDV parameters were protective factors.The area under the curve(AUC)for predicting poor prognosis,using individual parameters and serum hs-CRP levels alone and in combination,was 0.675,0.661,0.673,0.629,0.691,and 0.793,respec-tively,all exceeding the AUC of individual diagnostic indicators.Conclusion:Patients with chronic heart failure can be effectively assessed for their prognosis through echocardiography combined with hs-CRP level detection,providing valuable indicators for judging the patient's prognosis.This approach demonstrates excellent diagnostic and prognostic value and is worthy of clinical promotion and application.
万方数据
维普
