Study on the application effect of interventional therapy and its impact on hemorheology in patients with intracranial aneurysms
Objective:To investigate the application effect of interventional therapy in patients with intracrani-al aneurysms and its impact on hemorheology.Methods:A total of 96 patients with intracranial aneurysms admitted to Jiyuan People's Hospital in Henan Province from May 2021 to April 2023 were prospectively selected and divided into two groups with 48 patients in each group using the envelope method.The control group underwent craniotomy surgery,while the observation group underwent interventional therapy.The outcomes of the patients in both groups were evaluated 7 days after surgery,and the hemorheology,vascular endothelial function,inflammatory factors and complication rates were compared between the two groups.Results:The hemorheological levels decreased after in-tervention in both groups;the plasma viscosity,high-shear viscosity and low-shear viscosity levels in the obser-vation group were lower than those in the control group(P＜0.05).Both groups exhibited varying degrees of vas-cular endothelial function damage after intervention;The ET-1 level in the observation group was lower than that in the control group(P＜0.05),whereas the vWF and NO levels were higher than those in the control group(P＜0.05).CRP,IL-2,IL-6 and IL-8 levels were lower in the observation group than in the control group after intervention(P＜0.05).No statistical difference in safety was found between the two groups(P＞0.05).Conclusion:Interventional therapy for patients with intracranial aneurysms helps improve hemorheological levels,reduces the impact on vascular endothelial function,decreases inflammatory factor levels,and does not increase the incidence of postoperative complications,thus making it worthy of promotion and application.
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