Efficacy and safety of Keluoxin capsule combined with pancreatic kininogenase injection in the treatment of diabetic nephropathy
Objective:To analyze the efficacy and safety of Keluoxin capsules combined with pancreatic kini-nogenase injection in the treatment of diabetic nephropathy(DN).Methods:A retrospective analysis was conduc-ted on the data of 126 DN patients from Anyang People's Hospital between January 2021 and December 2023.Ac-cording to different treatment methods,63 patients treated with pancreatic kininogenase alone were assigned to the control group,and 63 patients treated with Keluoxin Capsules combined with pancreatic kininogenase were assigned to the observation group.The clinical efficacy,traditional Chinese medicine syndrome scores,renal function[glo-merular filtration rate(GFR),urinary microalbumin(mAlb),serum creatinine(Scr)],and safety were com-pared between the two groups.Results:The total clinical effective rate in the observation group was 90.48％(57/63),which was higher than the 76.19％(48/63)in the control group(P＜0.05).After treatment,Chinese medicine syndrome scores(including urine turbidity,five-heart distress heat,lassitude and fatigue,hortness of breath and lazy words,dry throat and mouth,limb pain,and excessive food and easy hunger)in the observation group were lower than those in the control group(P＜0.05).After treatment,the mAlb and Scr levels in the ob-servation group were lower than those in the control group,while the GFR was higher(P＜0.05).Conclusion:The combination of Keluoxin Capsules and pancreatic kininogenase injection for the treatment of DN is effective in alleviating symptoms,improving renal function,while also being safe.
万方数据
维普
