The effects of nimergoline combined with galantamine on neurokines and cerebral blood flow status in the treatment of mild to moderate vascular dementia
Objective:To analyze the effects of nimergoline combined with galantamine on neurotrophic factors and cerebral blood flow status in the treatment of mild to moderate vascular dementia.Methods:88 patients with mild to moderate vascular dementia admitted to Luoyang Petrochemical Hospital from January 2022 to October 2023 were enrolled in this study and randomly divided into combined group and acontrol group,with 44 patients in each group.The control group received galantamine treatment,while the combined group received nicergoline in addition to galantamine.Both groups were treated for 8 weeks.The therapeutic efficacy,neurotrophic factors,cerebral blood flow status before and after treatment,and adverse reactions during treatment were compared between the two groups.Results:After treatment,the total effective rate was higher in the combined group than in the control group(93.18％vs 77.27％,P＜0.05).The levels of serum brain-derived neurotrophic factor(BDNF)and the mean blood flow velocities of the middle cerebral artery(MCA),anterior cerebral artery(ACA)and posterior cerebral artery(PCA)increased in both groups after treatment,with higher levels in the combined group(P＜0.05).The levels of serum neuron-specific enolase(NSE)and visinin-like protein-1(VILIP-1)decreased in both groups after treatment,with lower levels in the combined group(P＜0.05).During treatment,the incidence of adverse reactions was similar between the two groups(9.09％vs 13.64％,P＞0.05).Conclusion:The combina-tion of nicergoline and galantamine has a good effect on the treatment of mild to moderate vascular dementia,impro-ving neurological factors and cerebral blood flow status,and is safe.
vascular dementiagalantaminenicergolinemild to moderateneurotrophic factorscerebral blood flow
万方数据
维普
