Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study

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外文摘要：Objective:To study the causality relationship between diastolic blood pressure(DBP)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of heart failure(HF)in the causality relationship by network Mendelian randomization(MR).Methods:Genome-wide analysis of DBR HRDRF,and HF was downloaded from the public database(Genome-Wide Analysis Study[GWAS])and was used to analyze the results and to conduct mediated MR analysis.Results:Analysis showedthat DBP was positively correlated with HRDRF(OR=1.0002,95％Cl:1.0001-1.0003,P=1.8076e-05)and DBP was positively correlated with HF(OR=1.0295,95％Cl:1.0221-1.0370,P=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95％CI:1.0000-1.0001,P=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBP and HRDRF was 24.69％.Conclusions:DBP can increase the risk of renal disease with renal failure,and HF may play an important role in mediating this causal relationship.

外文关键词：

atherosclerotic heart diseasediastolic blood pressureheart arrhythmiaheart failurehypertensive renal disease with renal failureMendelian randomization

作者：

Lei Pang、Zi-Jun Ding、Hong-Qiang Chai、Fei Li、Ming Wu、Wei-Bing Shuang

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作者单位：

Department of Urology,The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People's Hospital),Taiyuan,Shanxi 030012,China

First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi 030012,China

Department of Neonatology,Shanxi Children's Hospital,Taiyuan,Shanxi 030013,China

Department of Urology,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030012,China

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基金：

scientific research project of Shanxi Provincial Health Commission

项目编号：

2022073

出版年：

2024

DOI：

10.2478/FON-2024-0031

护理前沿(英文)

ISSN：2095-7718

年,卷(期)：2024.11(3)