GUI opera is being lost as a national intangible heritage.The investigation found that it has gone through the process of start-up,development and decline,and Musical Instruments,costumes,facial makeup,performance materials and other features are prominent.Based on the theory of cultural factors,the library of cultural factors of GUI opera is constructed,and its comprehensive application methods in interior design are put forward,such as the direct display of physical objects,the hollow-out and nesting of pattern shapes,the virtual and virtual and the overlapping,the combination and the collage.Let the experiencers produce cultural images through the senses,and finally form the theme space of GUI opera.The aim is to explore the inheritance and innovation of GUI opera culture in interior design,and expand the transmission path of traditional opera culture.