ObjectiveTo explore the scientific basis of processing technology of Polygonatum sibiricum Red. By the change of polysaccharides and saponins constituents during nine-steam-nine-bask processing.MethodsThe polysaccharides and saponins constituents determined with the markers of glucose and diosgenin by Uv-vis spectrophotometry. The ultrasonic ex-traction technology for saponins was optimized by a single factor experiment and an orthogonal experiment.ResultsThe content of polysaccharides will decrease with the streaming times increasing and saponins increased before they were the stable. The optimal extract conditions were obtained as folows: ethanol concentration 75%, ultrasonic time 40 min, the extraction tempera-ture 70℃, only one time.ConclusionThe optimal extraction method was repeatable. It can significantly increases the yield of saponins, and has a promising prospect of practical applications.