Objective To explore the clinical efficacy of Delphi pulmonary rehabilitation intervention after bronchial ther-moplasty in patients with moderate to severe COPD.Methods 82 patients with moderate to severe COPD in our hospital from January 2021 to January 2023 were selected for study.In the control group,conventional pulmonary rehabilitation was per-formed after bronchial thermoplasty,and the observation group used Delphi pulmonary rehabilitation on this basis.Compared the clinical efficacy,oxygenation function,quality of life,condition improvement,exercise endurance,number of acute exacer-bations,readmission rate and occurrence of respiratory adverse events.Results The apparent efficiency and total efficiency of the patients in the observation group were 82.93%and 95.13%respectively,which were higher than the 63.41%and 85.36%of the control group,and the difference between the two groups was statistically significant when comparing the grades of apparent,effective and ineffective.The difference between the two groups before and after the intervention was statistically significant;The differences of PCO2,respiratory index and oxygenation index before and after intervention in observation group were higher than those in control group.The difference of SGRQ,CAT and 6MWT before and after intervention in the observation group was compared,and the difference was statistically significant after t test;The differences of SGRQ,CAT and 6MWT before and after intervention in the observation group were higher than those in the control group.There was no significant difference in readmission rate between observation group and control group.The incidence of respiratory related adverse events in the ob-servation group was lower than that in the control group 3 months after surgery.Conclusion Delphi pulmonary rehabilitation in patients with moderate to severe COPD can effectively improve clinical efficacy,improve oxygenation function,improve quality of life,improve disease condition,improve exercise endurance,and reduce the number of acute exacerbations and the incidence of complications.