首页|长沙市孕妇妊娠早期血清全氟化合物暴露水平及影响因素研究

长沙市孕妇妊娠早期血清全氟化合物暴露水平及影响因素研究

Serum Levels of Per-and polyfluoroalkyl Substances and Their Determinants in Early Pregnant Women in Changsha City

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目的:探究长沙市孕妇妊娠早期血清全氟化合物浓度水平现状及其影响因素,为孕期保健和孕妇全氟化合物浓度研究提供依据.方法:选取湖南省长沙市妇幼保健院2022年孕检的孕妇进行问卷调查和血样检测,收集人口学特征、生活方式及孕检信息等资料,对全氟化合物浓度进行描述性分析并运用多元线性回归分析全氟化合物浓度的影响因素.结果:长沙市孕妇血清中共检出23种全氟化合物,其中10种全氟化合物的检出率达到100%,13种全氟化合物检出率超过90%.孕妇血清中的全氟化合物浓度之间呈现不同程度的相关性(r=0.11～0.93).全氟化合物总浓度值的中位数为7.572 9 ng/mL,全氟辛烷磺酸盐和全氟辛酸的浓度中位值分别为2.369 6 ng/mL和1.773 8 ng/mL.多元线性回归结果显示吸烟、年龄和住所打扫频率是全氟化合物浓度升高的危险因素,饮酒和孕次是全氟化合物浓度升高的保护因素.结论:长沙市孕妇体内全氟化合物暴露水平与国内其他内陆城市人群的全氟化合物暴露水平相近.全氟化合物浓度的正关联影响因素有吸烟、年龄、住所打扫频率;全氟化合物浓度的负关联影响因素有饮酒和孕次.
Objective To explore the level of per-and polyfluoroalkyl substances(PFAS)in Changsha's early pregnant women and the influencing factors of per-and polyfluoroalkyl substances,providing the prenatal care and evidence of concen-tration of PFAS in pregnant women.Method From among pregnant women who underwent prenatal examinations at Changsha Maternal and Child Health Hospital in Hunan Province in 2022,we selected participants for a questionnaire survey and blood sample testing.We collected pregnancy-related information,performed a descriptive analysis of PFAS concentration,and con-ducted a multiple linear regression analysis to identify factors that affect PFAS concentration.Results 23 PFAS were detected in the serum of pregnant women in Changsha,among which 10 compounds had a detection rate of 100%,and 13 compounds had a detection rate exceeding 90%.The median concentration of total PSASs was 7.572 9 ng/mL.The median concentrations of per-fluorooctane sulfonic acid(PFOS)and perfluoro-n-octanoic acid(PFOA)were 2.369 6 ng/mL and 1.773 8 ng/mL.The multiple linear regression results showed that smoking,age,residence cleaning frequency,drinking and gravidity were the influencing factors of PFAS concentration.Conclusion The concentration of PFAS of pregnant women in Changsha is similar to that of other inland cities.The positive correlation factors affecting the level of PFAS are smoking,age and residence cleaning frequency;the negative correlation factor is drinking and gravidity.

per-and polyfluoroalkyl substancesmultiple linear regressioninfluencing factorspregnant womenserum

林乐诗、李文娟、滕胜、杨奕、黎丽、彭芳、彭冬梅、秦露露、高晓

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湖南师范大学医学院"分子流行病学"湖南省重点实验室,长沙 410081

湖南师范大学附属长沙市妇幼保健院,长沙 410007

全氟化合物 多元线性回归 影响因素 孕妇 血清

湖南省自然科学基金青年基金湖南省卫生健康委科研课题湖南师范大学医学院开放课题湖南师范大学附属长沙市妇幼保健院区域遗传性出生缺陷防控研究湖南省重点实验室开放课题

2021JJ40367202212055647KF2021016HPKL2023024

2024

湖南师范大学学报(医学版)
湖南师范大学

湖南师范大学学报(医学版)

CSTPCD
影响因子：1.389
ISSN：1673-016X
年,卷(期)：2024.21(1)
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