In the central nervous system(CNS),oligodendrocyte precursor cells(OPCs)proliferate,migrate,and differenti-ate into oligodendrocytes(OLs),which subsequently form myelin structure that ensheathes the axons of neurons.Myelin enables fast saltatory impulse propagation,provides energy and nutrition for neurons,and facilitates the establishment and maintenance of cognition.Notably,the(re)generation of myelin requires substantial energy consumption.Glucose,the preferred energy re-source for many biological processes,plays a vital role in(re)myelination.Thus,we review the recent progress in the regulation of glucose metabolism on myelination to extend our understanding of myelination and to provide insights into the potential strat-egy for treating diseases of demyelination and neurodegeneration.
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