髓鞘生成与再生的糖代谢调控
Metabolic Regulation on Myelination and Remyelination
李平平 1蒋欣玥 1胡心悦 1李亚雯 1宋奕萱 1张明亮1
作者信息
- 1. 上海交通大学医学院组织胚胎学与遗传发育学系,上海市生殖医学重点实验室,上海 200025
- 折叠
摘要
中枢神经系统的少突胶质祖细胞通过增殖、迁移、分化,产生少突胶质细胞,进而形成包绕轴突的髓鞘结构.髓鞘不仅确保了神经电信号的跳跃式传导,还通过分泌神经营养因子等物质给予神经元能量和营养支持,参与哺乳动物脑高级功能的建立和维持.髓鞘形成和再生需要消耗大量能量.葡萄糖作为首选能量来源,参与了ATP产生、氧化应激调控等关键生物学过程,在髓鞘的形成和再生中发挥了重要作用.基于现有研究,本文综述了葡萄糖代谢对髓鞘形成的调控作用,为髓鞘脱失及其相关的神经系统疾病的理解和治疗提供线索.
Abstract
In the central nervous system(CNS),oligodendrocyte precursor cells(OPCs)proliferate,migrate,and differenti-ate into oligodendrocytes(OLs),which subsequently form myelin structure that ensheathes the axons of neurons.Myelin enables fast saltatory impulse propagation,provides energy and nutrition for neurons,and facilitates the establishment and maintenance of cognition.Notably,the(re)generation of myelin requires substantial energy consumption.Glucose,the preferred energy re-source for many biological processes,plays a vital role in(re)myelination.Thus,we review the recent progress in the regulation of glucose metabolism on myelination to extend our understanding of myelination and to provide insights into the potential strat-egy for treating diseases of demyelination and neurodegeneration.
关键词
糖代谢/少突胶质细胞/髓鞘生成/再生/神经退行性疾病Key words
carbohydrate metabolism/oligodendrocyte precursor cells/(re)myelination/neurodegenerative diseases引用本文复制引用
基金项目
国家自然科学基金委面上项目(32070866)
出版年
2024
NETL
NSTL
万方数据