首页|异麦芽糖酐铁治疗维持性血液透析患者缺铁性贫血的临床疗效分析

异麦芽糖酐铁治疗维持性血液透析患者缺铁性贫血的临床疗效分析

Analysis of clinical efficacy of Isomaltoside iron in patients with maintenance hemodialysis combined with iron defificiency anaemia

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目的:探究异麦芽糖酐铁在维持性血液透析(maintenance hemodialysis,MHD)合并缺铁性贫血((iron deficiency anemia,IDA)患者中应用的临床疗效.方法:选取2021年6月—2022年6月在本院血液净化中心规律行MDH合并IDA患者61例,按照治疗药物的不同分为蔗糖铁组和异麦芽糖酐铁组,其中蔗糖铁组29例,异麦芽糖酐铁组32例.蔗糖铁组患者予蔗糖铁治疗,异麦芽糖酐铁组患者予异麦芽糖酐铁治疗.连续治疗3个月后,比较两组患者生化指标变化及不良反应发生情况.结果:治疗前,两组患者各临床指标比较,差异均无统计学意义.治疗3个月后,两组患者血清尿素氮、血肌酐、尿酸、甲状旁腺素与治疗前比较无明显差异.两组患者血红蛋白、铁蛋白、转铁饱和度均高于治疗前,且异麦芽糖酐铁组高于蔗糖铁组,差异有统计学意义.同时,两组患者不良事件发生情况相比较,差异无统计学意义.结论:在维持性血液透析合并缺铁性贫血患者中应用静脉铁剂治疗,异麦芽糖酐铁在维持血红蛋白及铁蛋白方面并不低于蔗糖铁,且显效更快,未增加不良反应发生率,值得临床推广应用.
Objective To explore the clinical effificacy of Isomaltoside Iron in patients with maintenance hemodialysis(MHD)combined with iron defificiency anaemia(IDA).Methods 61 patients with MDH combined with IDA in our hospital's blood pu-rification center from June 2021 to June 2022 were selected and divided into sucrose iron group(29 cases)and isomaltoside iron group(32 cases)according to different treatment drugs.Patients in the sucrose iron group were treated with Sucrose Iron,while those in the isomaltoside iron group were treated with Isomaltoside Iron.After 3 months of continuous treatment,the changes in biochemical indicators(urea nitrogen,creatinine,PTH,hemoglobin,ferritin,transferrin saturation)and adverse reaction were compared between the two groups.Results Before treatment,there was no statistically significant difference between the clinical indicators of the two groups.After 3 months of treatment,there was no statistically significant difference in serum BUN,Scr,UA and PTH between the two groups.both the two groups had an increase in hemoglobin、ferritin and transferrin saturation levels,and the isomaltoside iron Group increased more significantly than sucrose iron group,which was statistically significant.At the same time,There is no statistically significant difference in the incidence of adverse events between the two groups of patients.Conclusion Compared with sucrose iron,isomaltoside iron induced a non-inferior haematological response,comparably low rates of hypersensitivity reactions,and exhibits faster effects,without increasing the incidence of adverse reactions.

hemodialysisisomaltoside ironsucrose ironiron-deficiency anemia

蒋亚芬、武蓉

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湖南师范大学附属长沙市第四医院,长沙 410006

血液透析 异麦芽糖酐铁 蔗糖铁 缺铁性贫血

湖南省卫生健康委科研计划项目

D202303057573

2024

湖南师范大学学报(医学版)
湖南师范大学

湖南师范大学学报(医学版)

CSTPCD
影响因子:1.389
ISSN:1673-016X
年,卷(期):2024.21(2)