Objective To observe the changes of myocardial enzymology,neuroendocrine and cardiac function in healthy young and middle-aged men before and after acute short-term plateau exposure;and to explore the effects and possible mecha-nisms of acute short-term plateau exposure on cardiac tissue cell function and neuroendocrine.Methods 50 healthy young and middle-aged male volunteers were randomly selected to collect physiological indices:heart rate(HR),respiratory rate(R),systolic blood pressure(SBP),diastolic blood pressure(DBP),and oxygen saturation(SaO2)at 7:00 am 1 day before entering plateau(100 m above sea level),and 15 days after short-term exposure to plateau in an acute condition(3 000 m above sea lev-el)in a fasting and seated position;cardiac enzymology and neuroendocrine function of cardiac tissues and cardiovascular func-tion of cardiac tissues and cardiac cells were detected by using a fully automated biochemical analyzer.Neuroendocrine-related indexes:thyroid stimulating hormone(TSH),total thyroxine(TT4),free thyroxine(FT4),free tri-iodothyronine(FT3),total tri-iodothyronine(TT3),and cortisol(CORT);and color Doppler ultrasound diagnostic instrument was used to check the cardiac function indexes:right ventricular internal diameter(RV),right atrial internal diameter(RA),left ventricular diastolic internal diameter(LV),and left atrial internal diameter(LA).(LV),left atrial internal diameter(LA),aortic root internal diameter(AO),pulmonary artery internal diameter(PA),left ventricular long-axis shortening(LVFS),left ventricular ejection fraction(LVEF),stroke volume(SV),and left ventricular end-diastolic volume(LVEDV),comparing differences in indicators before and after acute short-term plateau exposure.Results Compared with before entering the plateau,the physiological parameter indicators of young and middle-aged men after 15 days of acute short-term plateau exposure:HR increased significantly,R increased,SBP increased,SaO2 decreased,DBP increased,and MAP increased,and the differences were statistically significant;cardiac en-zyme indicators:LDH,CK-MB,CK,HBDH,IMA,Mb,cTnT,and hs-CRP were significantly elevated,and the differences were all statistically significant;neuroendocrine-related indices:TSH,TT4,FT4,FT3,TT3,and CORT were significantly elevated;and cardiac function indices:RV,RA,LV,LA,LVFS,LVEF,and SV,LVEDV were all decreased,and AO and PA were all increased,and the differences were all statistically significant.Conclusion Short-term acute plateau exposure can lead to acute plateau hypoxic myocardial injury,which is mainly manifested as oxidative stress,resulting in damage to myocardial cell mem-branes and outflow of relevant cardiac enzymes from myocardial cell membranes,which to a certain extent caused a decrease in cardiac compensatory capacity.
acute-access short-termplateau exposurelow-pressure hypoxiayoung and middle-aged men
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