Objective To investigate the efficacy of percutaneous balloon compression(PBC)and radiofrequency ther-mocoagulation(RFT)in the treatment of primary trigeminal neuralgia and its effect on serum neurotransmitters.Methods 100 patients with primary trigeminal neuralgia admitted to the pain department of our hospital from January 2021 to December 2022 were selected as the research objects.According to the random number table method,the patients were randomly divided into two groups.50 patients treated with RFT were in the RFT group,and 50 patients treated with PBC were in the PBC group.The clinical efficacy[barrow neurological institute(BNI)pain intensity scale],pain(numeric rating scales,NRS),serum neu-rotransmitters[serum substance P(SP),β-endorphin β(-EP)and 5-hydroxytryptamine(5-HT)],sleep status and recovery quality[pittsburgh sleep quality index(PSQI)and postoperative quality of recovery-40 que were compared between the two groups.Results There was no significant difference in the total remission rate between the two groups at 3 days and 3 months after operation.There was no significant difference in NRS scores between the two groups before operation,3 days after opera-tion,1 month after operation and 3 months after operation.At 3 days after operation,SP in both groups decreased,and that in the observation group was lower.β-EP and 5-HT in both groups increased,and those in the observation group were higher.Three days after operation,the PSQL scores of the two groups decreased,and that of the observation group was lower than that of the control group.The QoR-40 scores of the two groups did not increase,and there was no difference between the two groups.The incidence of hypoesthesia/facial numbness and masseter weakness in the observation group was higher than that in the control group,and the incidence of corneal discomfort was lower than that in the control group.Conclusion The clinical efficacy of PBC and RFT in patients with primary trigeminal neuralgia is similar.
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