Objective To explore the effect of grid like photocoagulation in the macular region combined with Leizumab on serum Vascular endothelial growth factor(VEGF)and interleukin-6(IL-6)levels in patients with diabetes macular edema(DME).Methods Patients with DME 98 cases admitted to Chengdu 363 Hospital from January 2021 to January 2023 were selected and randomly divided into two groups using a single blind randomized control method based on a random number table,with 49 pa-tients in each group.The patients in the control group were treated with macular grid photocoagulation,and the patients in the observation group were treated with macular grid photocoagulation combined with leizumab.There were compared two groups preoperative,postoperative 1 month and 6 TMV,CME and corrected best visual,before operation and 6 months after opera-tion serum VEGF and IL-6,and 6 months after operation curative effect.Results Compared preoperative,TMV and CME of to groups were decreased at postoperative 1 month and 6 months and in the observation group were lower than those in the Com-pared preoperative,two groups best corrected visual acuity were increased of postoperative 1 month and 6 months;at postop-erative 1 month and 6 months,observation group best corrected visual acuity higher control group.Compared preoperative,two groups serum VEGF and IL-6 levels were decreased of postoperative 6 months;at postoperative 6 months,observation group serum VEGF and IL-6 levels lower control group.At postoperative 6 months,observation group total effective rate was higher than control group.Conclusion Macular grid photocoagulation combined with rezumab is effective in treating DME,it can ef-fectively improve vision,and relieve macular edema,and reduce serum IL-6 and VEGF levels.
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