Analysis of bacterial distribution and drug resistance of 526 patients with diabetes mellitus complicated by urinary tract infection in a hospital of Hunan
Objective To study the pathogenic bacteria distribution and drug resistance of urinary system infection in in-patients with diabetes,and to provide scientific basis for clinical screening of antibiotics to guide rational drug use.Methods 526 midcourse urine samples from inpatients with diabetes complicated with urinary system infection in a hospital of Hunan Province from January 2021 to May 2023 were selected,and then isolation culture and drug sensitivity experiments were carried out to observe and compare the distribution of pathogenic bacteria and drug resistance rates among patients of different genders and ages.Results A total of 609 strains of bacteria were isolated and cultured.The main strains of Gram-negative bacteria(G-)were Escherichia coli and Klebsiella pneumoniae,and the main strains of Gram-positive bacteria(G+)were Enterococcus fae-cium and Enterococcus faecalis.The resistance rate of Escherichia coli to levloxacin and ciprofloxacin was 77.83%and 66.02%,respectively,and it was highly sensitive to tigacycline and colistin.The resistance rate of Klebsiella pneumoniae to levofloxacin was the highest(60.27%).Among the main G+bacteria,Enterococcus faecium had high resistance rates to penicillin,ampicil-lin,ciprofloxacin,levofloxacin and erythromycin(98.17%,92.66%,88.07%,93.58%,93.58%),and was sensitive to quinup-tidine/dafoptidine,linezolid,vancomycin,tetracycline and tigacycline,respectively.Enterococcus faecalis had high resistance rates to erythromycin,tetracycline,quinuptine/Dafoptene(96.67%,96.67%,76.67%,respectively),and was highly sensitive to penicillin,ampicillin,ciprofloxacin,levofloxacin,vancomycin and tigacycline.Escherichia coli accounted for the highest proportion in different gender groups,and the isolation rate of Escherichia coli in female patients was significantly increased.In different age groups,with the increase of host age,the sensitivity of Escherichia coli to different antibiotics showed different trends.Conclusion The main pathogenic bacteria in patients with diabetes complicated with urinary system infection are gram-negative bacteria,and the resistance rate of these pathogenic bacteria to commonly used antibiotics is significantly different,and it changes with the difference of gender and age.This study provides a basis for the rational clinical use of drugs in Hunan Prov-ince,the prevention of the spread of drug-resistant bacteria,and the active exploration and research of new treatments to deal with the increasingly severe situation of bacterial resistance.
diabetesurinary system infectionbacterial distributiondrug resistance
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