Objective To explore the changes and clinical significance of serum soluble vascular endothelial growth factor receptor-1(sFlt-1),E-cadherin and interferon γ(IFN-γ)in patients with unexplained recurrent spontaneous abortion(URSA).Methods A total of 146 patients with URSA and 80 normal pregnant women who underwent prenatal examination were enrolled as abortion group and control group between January 2021 and January 2023,respectively.The clinical data and changes of se-rum sFlt-1,E-cadherin and IFN-γ in the two groups were compared.The influencing factors of URSA were analyzed by multi-variate Logistic regression analysis,and the predictive value of sFlt-1,E-cadherin and IFN-γ for URSA was analyzed.Results The levels of serum sFlt-1 and IFN-γ in abortion group were higher than those in control group,while E-cadherin level was lower than that in control group(t=8.520;t=4.254;t=6.643,P<0.05).Pearson correlation analysis showed that serum sFlt-1 level in URSA patients was negatively correlated with E-cadherin,while positively correlated with IFN-γ(r=-0.286;r=0.392,P<0.05).Serum E-cadherin in URSA was negatively correlated with IFN-γ(r=-0.272,P<0.05).Binary Logistic regression analysis showed that age,sFlt-1,E-cadherin and IFN-γ were independent risk factors of URSA.ROC curves analysis showed that AUC of serum sFlt-1 combined with E-cadherin and IFN-γ for predicting URSA was 0.909,greater than that of single index(0.864,0.666,0.764,Z=2.892;Z=6.562;Z=4.089,P<0.05).Conclusion The levels of serum sFlt-1 and IFN-γ are increased,while E-cadherin level is decreased in URSA patients,and all the three indexes have certain value in the prediction and diagnosis of URSA.
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