气道廓清技术对卒中相关肺炎患者疗效以及血清CGRP、MMP-9水平的影响
Effect of airway clearance technique on curative effect and serum CGRP and MMP-9 levels in patients with stroke-related pneumonia
曹雪萍 1熊程成 1张文彩 1李晓芳1
作者信息
- 1. 郴州市第一人民医院 重症康复科,郴州 423000
- 折叠
摘要
目的:探究气道廓清技术对卒中相关肺炎患者疗效以及血清降钙素基因相关肽(calcitoningene-relatedpeptide,CGRP)、基质金属蛋白酶(matrix metalloprotein,MMP)-9水平的影响.方法:选择2020年6月―2021年12月我院收治的100例脑卒中相关肺炎患者作为本次的研究对象,采用随机数字表法将100例患者分为研究组与对照组,每组50例.对照组患者采用常规治疗与干预方案,研究组在对照组干预措施基础上应用气道廓清技术.对比两组患者疗效、血清CGRP、MMP-9水平.结果:研究组治疗有效率为98.0%显著高于对照组86.0%;干预前,两组患者的咳痰、呼吸困难评分、CPIS评分、CGRP水平、MMP-9水平之间无显著差异;干预后,两组患者的咳痰、呼吸困难评分、CPIS评分、MMP-9水平、均显著降低,CGRP水平均显著升高,且研究组咳痰、呼吸困难评分、CPIS评分、MMP-9水平低于对照组,CGRP水平高于对照组.结论:气道廓清技术能够显著改善卒中相关肺炎患者疗效,并使患者血清CGRP水平显著上升、MMP-9水平显著下降.
Abstract
Objective To explore the effect of airway clearance technology on the curative effect and serum calcitoningene-relatedpeptide(CGRP)and matrix metalloprotein(MMP)-9 levels in patients with stroke related pneumonia.Methods 100 patients with stroke-related pneumonia treated in our hospital from June 2020 to December 2021 were selected as the research objects.100 patients were divided into experimental group and control group by random number table method,with 50 cases in each group.The patients in the control group were treated with routine treatment and intervention,and the patients in the exper-imental group were treated with airway clearance technology on the basis of the intervention measures in the control group.The curative effect,serum CGRP and MMP-9 levels were compared between the two groups.Results The effective treatment rate in the study group was 98.0%,which was significantly higher than that in the control group at 86.0%.Before the intervention,there were no significant differences between the two groups in terms of sputum expectoration,dyspnea scores,CPIS scores,CGRP levels,or MMP-9 levels.After the intervention,sputum expectoration scores,dyspnea scores,CPIS scores,and MMP-9 levels significantly decreased in both groups,while CGRP levels significantly increased.Additionally,the study group showed lower sputum expectoration scores,dyspnea scores,CPIS scores,and MMP-9 levels,and higher CGRP levels compared to the control group.Conclusion Airway clearance technology can significantly improve the curative effect of patients with stroke-related pneumonia,and significantly increase the level of serum CGRP and significantly decrease the level of MMP-9.
关键词
气道廓清技术/卒中相关肺炎/疗效/降钙素基因相关肽/基质金属蛋白酶-9Key words
airway clearance technology/stroke associated pneumonia/curative effect/calcitoningene-relatedpeptide/matrix metalloprotein-9引用本文复制引用
出版年
2024
NETL
NSTL
万方数据